Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster
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چکیده
منابع مشابه
Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster.
Human placental lactogen (hPL) and human growth hormone (hGH) are members of a multigene family that share amino acid sequence homology and similarity in gene structure and nucleotide sequence, but differ in both function and expression. To determine the sequence requirements for tissue specific expression recombinant plasmids containing the members of the hPL-hGH multigene family and flanking ...
متن کاملLinkage arrangement of human placental lactogen and growth hormone genes.
Human placental lactogen (hPL) and growth hormone (hGH) are two hormones thought to have evolved from a common ancestral gene (along with prolactin), yet they have quite different functions and specificities. The nucleic acid sequences of the respective cDNAs of the two genes share considerable homology, as well as the existence of multiple forms of each gene within the genome. In this study we...
متن کاملRecombinant hormones from fragments of human growth hormone and human placental lactogen.
Peptide fragments generated by limited plasmin digestion and reduction of human growth hormone (hGH) and human placental lactogen (hPL) were recombined to produce biologically active molecules consisting of the NH2-terminal two-thirds of one hormone molecule linked to the COOH-terminal one-third of the other. Plasmin-cleaved hPL and hGH each consist of an NH2-terminal fragment (1-134) connected...
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16 ROGERS, B. L., SOBNOSKY, M. G. & SAUNDERS, G. F. (1985). Transcriptional enhancer within the human placental lactogen and growth hormone multigene cluster. J . Biol. Chem. (in press). 17 PICARD, D. & SCHAFFNER, W. (1984). A lymphocyte-specific enhancer in the mouse immunoglobulin gene. Nature 307, 80-82. 18 EPHRUSSI, A., CHURCH, G. M., TONEGAWA, S. & GILBERT, W. (1985). Science 227, 134-140....
متن کاملThyroid hormone receptors bind to defined regions of the growth hormone and placental lactogen genes.
The intracellular receptor for thyroid hormone is a protein found in chromatin. Since thyroid hormone stimulates transcription of the growth hormone gene through an unknown mechanism, the hypothesis that the thyroid hormone-receptor complex interacts with defined regions of this gene has been investigated in a cell-free system. Nuclear extracts from human lymphoblastoid IM-9 cells containing th...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1986
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/14.19.7647