Transcriptional control of terminal nephron differentiation
نویسندگان
چکیده
منابع مشابه
Transcriptional control of terminal nephron differentiation.
Terminal differentiation of epithelial cells into more specialized cell types is a critical step in organogenesis. Throughout the process of terminal differentiation, epithelial progenitors acquire or upregulate expression of renal function genes and cease to proliferate, while expression of embryonic genes is repressed. This exquisite coordination of gene expression is accomplished by signalin...
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Despite a wealth of knowledge regarding the early steps of epithelial differentiation, little is known about the mechanisms responsible for terminal nephron differentiation. The bradykinin B2 receptor (B2R) regulates renal function and integrity, and its expression is induced during terminal nephron differentiation. This study investigates the transcriptional regulation of the B2R during kidney...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2008
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00562.2007