Transcription Factors in Lymphocyte Development— T and B Cells Get Together

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

surface proteins B220 and CD19 are generated (reviewed by Melchers et al., 1995). These proteins serve as early B lineage developmental markers and execute important functions in mature B cells. An early program of gene expression induced specifically in pro B cells (Ig) receptor-associated signaling proteins Ig␣ (mb-1) Harvard Medical School and Ig␤ (B29), and the surrogate light chains ␭5 and...

Lymphocyte Development — B- and T-Cell Development

The roles of transcription factors in B lymphocyte commitment, development, and transformation.

Studies of normal blood cell development and malignant transformation of hematopoietic cells have shown that the correctly regulated expression of stage- and lineage-specific genes is a key issue in hematopoiesis. Experiments in transgenic mice have defined a number of transcription factors such as SCL/Tal, core-binding factor/acute myeloid leukemia, and c-myb, all crucial for the establishment...

Requirement for deoxycytidine kinase in T and B lymphocyte development.

Deoxycytidine kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. dCK phosphorylates and therefore activates nucleoside analog prodrugs frequently used in cancer, autoimmunity, and viral infections. In contrast to its well established therapeutic relevance, the biological function of dCK remains enigmatic. Highest...

A SURVEY OF CELLULAR IMMUNITY, TOTAL T-LYMPHOCYTE, T-ACTIVE , B-LYMPHOCYTE A ND T-CELL FUNCTION IN RELATION TO PHYTOHEMAGGLUTININ (PHA) IN THALASSEMIC PATIENTS

The aim of this study was to evaluate the immune system and lymphocyte function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. The patients consisted of 20 splenectomized and 21 non-splenectomized patients. They were treated with Desferal, and had received repeated blood transfusion. Laboratory investigations included measurement of total T lymphocyt...