Transcription elongation factor hSPT5 stimulates mRNA capping
نویسندگان
چکیده
منابع مشابه
Transcription elongation factor hSPT5 stimulates mRNA capping.
RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme. hSPT5 stimulated capping enzyme guanylylation and mRNA capping by severalfold. Although RNA 5'-triphosphatase activity was unaffected, binding to this domain in the full-length enzyme is likel...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1999
ISSN: 0890-9369
DOI: 10.1101/gad.13.14.1774