Tranilast Suppresses Intimal Hyperplasia in the Balloon Injury Model and Cuff Treatment Model in Rabbits
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چکیده
منابع مشابه
Zinc reduces intimal hyperplasia in the rat carotid injury model.
BACKGROUND The response to arterial injury following balloon dilatation is known to involve proliferative and inflammatory processes. The current widespread use of stents to maintain arterial patency not only does not eliminate but possibly exaggerates the proliferative and inflammatory phenotype and although drug-eluting stents are available, their long-term safety is yet to be determined. Zin...
متن کاملCCN1 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model.
OBJECTIVE CCN1 (Cyr61) is an extracellular matrix-associated protein involved in cell proliferation and survival. CCN1 is bound to vascular smooth muscle cells (VSMCs) via integrins and is expressed in VSMCs in atherosclerotic lesions, suggesting involvement in the regulation of vascular smooth muscle cell (VSMC) proliferation and atherosclerosis. We hypothesized that knockdown of CCN1 may inhi...
متن کاملBTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model.
Basic transcription element-binding protein 2 (BTEB2) is a regulator of the proliferation and phenotypic changes of vascular smooth muscle cells (SMCs). The aim of the present study was to determine whether or not BTEB2 knockdown inhibits balloon injury-induced neointimal hyperplasia attributed to the proliferation and phenotypic changes of vascular SMCs. We found that the knockdown of BTEB2 wi...
متن کاملSodium Ferulate Inhibits Neointimal Hyperplasia in Rat Balloon Injury Model
BACKGROUND/AIM Neointimal formation after vessel injury is a complex process involving multiple cellular and molecular processes. Inhibition of intimal hyperplasia plays an important role in preventing proliferative vascular diseases, such as restenosis. In this study, we intended to identify whether sodium ferulate could inhibit neointimal formation and further explore potential mechanisms inv...
متن کاملPrevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model.
OBJECTIVES The role of P-selectin in the process of restenosis was evaluated using a recombinant immunoglobulin (Ig) chimera form of its ligand, soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig), as a competitive inhibitor for the natural ligand on leukocytes. BACKGROUND Inflammation and coagulation activation after vascular injury may be an important factor in the development of restenosi...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1996
ISSN: 0021-5198
DOI: 10.1254/jjp.70.321