Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study
نویسندگان
چکیده
منابع مشابه
Multiple trait analysis of genetic mapping for quantitative trait loci.
We present in this paper models and statistical methods for performing multiple trait analysis on mapping quantitative trait loci (QTL) based on the composite interval mapping method. By taking into account the correlated structure of multiple traits, this joint analysis has several advantages, compared with separate analyses, for mapping QTL, including the expected improvement on the statistic...
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Traditional genetic mapping has largely focused on the identification of loci affecting one, or at most a few, complex traits. Microarrays allow for measurement of thousands of gene expression abundances, themselves complex traits, and a number of recent investigations have considered these measurements as phenotypes in mapping studies. Combining traditional quantitative trait loci (QTL) mappin...
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In 2001, Sen and Churchill reported a general Bayesian framework for quantitative trait loci (QTL) mapping in inbred line crosses. The framework is a powerful one, as many QTL mapping methods can be represented as special cases and many important considerations are accommodated. These considerations include accounting for covariates, nonstandard crosses, missing genotypes, genotyping errors, mu...
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BACKGROUND Expression quantitative trait loci (eQTL) have been identified using tissue or cell samples from diverse human populations, thus enhancing our understanding of regulation of gene expression. However, few studies have attempted to identify eQTL in racially admixed populations such as Hispanics. METHODS We performed a systematic eQTL study to identify regulatory variants of gene expr...
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With the increasing number of polymorphic markers identified on the genetic map, positional cloning has become an extremely powerful tool, permitting the linkage and identification of a large number of disease genes. As the human genome project pro gresses and the gene map becomes as dense as the microsatellite polymorphism map, scientists will identify more disease genes through a combination...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2008
ISSN: 1471-2164
DOI: 10.1186/1471-2164-9-242