منابع مشابه
Being Positive about Selection
H ow has language developed in humans and what genetic changes underlie our unique cognitive abilities? Accounts of positive selection that lead to such abilities in humans fascinate us because of the insight they provide into our own evolution, and into the many genetic differences that distinguish us from other apes. The genes that became fi xed in our lineage as a result of positive selectio...
متن کاملSpecific Positive Selection of Lymphocytes
The population of thymus-derlved (T) lymphocytes reactive to strong histocompatibility (H) 1 alloantigens (HARC) is peculiar in two respects in comparison to lymphocytes~responsive to other antigens: first, the T cells reactive to any given strong H antigen outnumber by two to three orders of magnitude the T cells responsive to more conventional antigens (1-3); and secondly, the frequency of HA...
متن کاملGenomic insights into positive selection.
The traditional way of identifying targets of adaptive evolution has been to study a few loci that one hypothesizes a priori to have been under selection. This approach is complicated because of the confounding effects that population demographic history and selection have on patterns of DNA sequence variation. In principle, multilocus analyses can facilitate robust inferences of selection at i...
متن کاملHitchhiking under positive Darwinian selection.
Positive selection can be inferred from its effect on linked neutral variation. In the restrictive case when there is no recombination, all linked variation is removed. If recombination is present but rare, both deterministic and stochastic models of positive selection show that linked variation hitchhikes to either low or high frequencies. While the frequency distribution of variation can be i...
متن کاملModel Selection Based on Tracking Interval Under Unified Hybrid Censored Samples
The aim of statistical modeling is to identify the model that most closely approximates the underlying process. Akaike information criterion (AIC) is commonly used for model selection but the precise value of AIC has no direct interpretation. In this paper we use a normalization of a difference of Akaike criteria in comparing between the two rival models under unified hybrid cens...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2002
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg942