منابع مشابه
Tracking down noncoding RNAs.
U ntil relatively recently, RNA has taken a predominantly backstage role compared to protein in genome studies. However, this is changing dramatically with the discovery of a plethora of RNAs that do not act as messenger (mRNA), transfer (tRNA), or ribosomal (rRNA) RNAs (1–3). These noncoding RNAs (ncRNAs) play a role in a variety of processes such as transcriptional regulation, chromosome repl...
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BACKGROUND Malignant tumours of the duodenum are rare and often difficult to diagnose. Due to the small clinical experience with duodenal malignancies their prognosis is unknown and resection is the treatment of choice. CASE REPORT Adding to a small series of incidental tumours, we report the case of a 65-year-old patient with primary extranodal (MALT-) lymphoma of the duodenum infiltrating t...
متن کاملAntisense-mediated down-regulation of the human huntingtin gene.
The present study determines whether the expression of the huntingtin gene might be subject to antisense (AS)-mediated down-regulation. A series of AS oligodeoxynucleotides (ODNs) complementary to the huntingtin transcript [i.e., nucleotide (nt) -25 to 35] were designed and synthesized, and the AS efficacy was investigated by using a combination of in vitro transcription and translation to mimi...
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Huntington's disease (HD) is a fatal, neurodegenerative disorder in which patients suffer from mobility, psychological and cognitive impairments. Existing therapeutics are only symptomatic and do not significantly alter the disease progression or increase life expectancy. HD is caused by expansion of the CAG trinucleotide repeat region in exon 1 of the Huntingtin gene (HTT), leading to the form...
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Understanding subcellular dynamic processes governing pathogenic mechanisms is a necessary step towards the development of new drugs and strategies against infectious diseases. Subcellular pathogenic mechanisms, such as viral invasion processes involve highly dynamic nanometric-scale objects and rapid molecular interactions that require the study of individual particle paths. Single-particle tr...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2004
ISSN: 1078-8956
DOI: 10.1038/nm0804-776