Toxicology and Carcinogenesis Study of Senna in C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice
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15 صفحه اولFolate deficiency provides protection against colon carcinogenesis in DNA polymerase beta haploinsufficient mice.
Aging and DNA polymerase beta deficiency (beta-pol(+/-)) interact to accelerate the development of malignant lymphomas and adenocarcinoma and increase tumor bearing load in mice. Folate deficiency (FD) has been shown to induce DNA damage repaired via the base excision repair (BER) pathway. We anticipated that FD and BER deficiency would interact to accelerate aberrant crypt foci (ACF) formation...
متن کاملEffect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase β Haploinsufficient Mice
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ژورنال
عنوان ژورنال: Toxicologic Pathology
سال: 2012
ISSN: 0192-6233,1533-1601
DOI: 10.1177/0192623312464304