Toxicity of polybrominated biphenyls (Firemaster BP-6) in rodents
نویسندگان
چکیده
منابع مشابه
Toxicity of polybrominated biphenyls Firemaster BP-6 in rodents.
Pregnant rodents were fed concentrations of a mixture of polybrominated biphenyls (Firemaster BP-6) during the pregnancy. The material appears to be weakly teratogenic, causing exencephaly and cleft palate in mice. Decreasing birth weight with increasing dosage of the material was seen in both mice and rats. Nonpregnant mice fed 1000 ppm Firemaster BP-6 for 11 days had a marked increase in live...
متن کاملEM changes and other toxic effects of firemaster BP-6 (polybrominated biphenyls) in the mouse.
Groups of Swiss ICR mice were fed 1000 ppm polybrominated biphenyls (FireMaster BP-6) in rodent chow for 4, 8, 11, and 14 days. Control groups were fed standard rodent chow without FireMaster BP-6. Animals were killed at the end of each feeding period and the livers examined by electron microscopy. EM changes noted were progressive increase in size of hepatocytes, a decrease in rough endoplasmi...
متن کاملEffect of diet on the hepatotoxicity of polybrominated biphenyls (FireMaster PB-6).
The consumption of diets formulated with Cruciferae vegetables, e.g., cauliflower, cabbage, and Brussels sprouts, has been shown to result in a stimulation of the intestinal and hepatic microsomal enzyme systems in rats. This study was designed to determine if this increase in intestinal and hepatic microsomal enzyme activity affected the hepatic response to polybrominated biphenyls (PBB). Afte...
متن کاملToxicity and residue studies in dairy animals with FireMaster FF-1 (polybrominated biphenyls)
Two studies (one in Holstein calves and one in Holstein cows) were conducted to determine potential toxicity and residue levels following oral ingestion of polybrominated biphenyls (PBB). The material was FireMaster FF-1. Administration was by gelatin capsules. Doses in calves were 0.1, 1.0, 10, or 100 mg/kg body weight, while doses in cows were equivalent to 0.01, 0.1, 1.0, or 10 ppm in the di...
متن کاملCytogenetic and teratogenic test of polybrominated biphenyls in rodents.
Previously we reported negative terata and c-mitosis synergism of FireMaster (polybrominated biphenyls) with colchicine in subacutely treated rats. Now we report absence of chromosome aberrations from FireMaster and absence of c-mitosis synergism of FireMaster and colchicine in male mice. For the study of chromosome aberrations groups of three mice received 0, 50, or 500 mg/kg FireMaster or 4.5...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Research
سال: 1975
ISSN: 0013-9351
DOI: 10.1016/0013-9351(75)90034-1