Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment

Currently no therapy of acute lymphoblastic leukemia is conceivable without L-asparaginase drugs, with its antileukemic effect by extracellular asparagine depletion, thus preventing admission to leukemic cell. Besides high antitumor effect, drugs have side and toxic effects, such as hypersensitivity reactions, thrombosis, pancreatitis / pancreatic necrosis, hepatotoxicity. For safety profile improvement a technology pegylation was lay down PEG-aspargase drug produced. This has less effects recommended first-line leukemia. Drug monitoring for assessment the effectiveness toxicity optimal. Such individualization helps dose finding decrease frequency severity effects.