Toxicity and efficacy of flat-dosed versus body-surface area (BSA)-dosed capecitabine

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Once-daily dosed gentamicin is more nephrotoxic than once-daily dosed tobramycin in clinically infected patients.

1 integron showed 100% nucleotide sequence identity to the corresponding segment of a plasmid from the human clinical P. aeruginosa strain B3 isolated in Guangzhou (accession no. EU588392). Moreover, the 3 ′ conserved region of the integron (qacED1 and sul1) and the upstream region of the bla IMP-45 gene including aacA4, the 5 ′ conserved segment (intI1) of the integron and a Tn1403-like transp...

متن کامل

Flat-fixed dosing versus body surface area based dosing of anticancer drugs: there is a difference.

In a recent review, Mathijssen et al. [1] proposed using flatfixed dosing regimens rather than body surface area (BSA)based dosing for anticancer drugs because “it does not seem worse than using BSA-based dosing” with regard to pharmacokinetic variability. We feel that this statement, together with other recent publications arguing against BSAbased dosing, requires a counterpart. Most cytotoxic...

متن کامل

MicroRNA-155 deficient mice experience heightened kidney toxicity when dosed with cisplatin.

The development of nephrotoxicity limits the maximum achievable dosage and treatment intervals for cisplatin chemotherapy. Therefore, identifying mechanisms that regulate this toxicity could offer novel methods to optimize cisplatin delivery. MicroRNAs are capable of regulating many different genes, and can influence diverse cellular processes, including cell death and apoptosis. We previously ...

متن کامل

Kinetics and disposition of orally dosed sodium chlorate in sheep.

Experiments were conducted in sheep to determine excretory characteristics of sodium chlorate after a single oral dose. In Exp. 1, lambs (n = 16; age = 8.1 ± 1.7 d; BW = 8.2 ± 1.1 kg; mean ± SD) were dosed orally with 0, 30, 60, or 90 mg/kg BW of sodium chlorate. Twenty-four hours after exposure chlorate residues were dose dependent (P < 0.05) in small intestinal contents, serum, and urine, but...

متن کامل

Acute toxicity and cholinesterase inhibition in chicks dosed orally with organophosphate insecticides.

Acute toxic effects of three commonly used insecticidal preparations of the organophosphates chlorpyrifos, diazinon, and dichlorvos were examined in mixed breed broiler chicks, and cholinesterase activity in plasma and brain were measured. The acute (24 h) oral median lethal doses (LD50) of chlorpyrifos, diazinon, and dichlorvos were 10.79 mg kg(-1), 6.32 mg kg(-1), and 6.30 mg kg(-1), respecti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2017

ISSN: 0923-7534

DOI: 10.1093/annonc/mdx393.053