Toxicity and Carcinogenicity Studies of Oxazepam in the Fischer 344 Rat
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Toxicity and carcinogenicity studies of oxazepam in the Fischer 344 rat.
Oxazepam and related benzodiazepines are used in the treatment of anxiety. Carcinogenicity studies of oxazepam were performed with the F344 rat because of marked differences in tumor responses observed in NTP studies with B6C3F1 and Swiss-Webster mice compared to the results of Sprague-Dawley rat studies submitted to the FDA by a manufacturer to support registration of the drug. Groups of 50 ma...
متن کاملChronic toxicity and oncogenicity of decamethylcyclopentasiloxane in the Fischer 344 Rat.
Decamethylcyclopentasiloxane (D5) is a cyclic polydimethylsiloxane used in the synthesis of silicon-based materials and as a component in consumer products. Male and female Fischer 344 rats were exposed to D5 vapor (0, 10, 40, 160 ppm; whole-body inhalation) for 6 h/d, 5 d/wk, for up to 104 weeks. Microscopic examination of tissues revealed test article effects at 160 ppm in the upper respirato...
متن کاملSubchronic toxicity evaluation of potassium bromate in Fischer 344 rats.
Male F344 rats were exposed to potassium bromate (KBrO₃) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400 mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, thyroid, and tunica vaginalis). Weekly body weight and water consumption means w...
متن کاملDysfunctional play and dopamine physiology in the Fischer 344 rat.
Juvenile Fischer 344 rats are known to be less playful than other inbred strains, although the neurobiological substrate(s) responsible for this phenotype is uncertain. In the present study, Fischer 344 rats were compared to the commonly used outbred Sprague-Dawley strain on several behavioral and physiological parameters in order to ascertain whether the lack of play may be related to compromi...
متن کاملThe Fischer 344 rat as a model of presbycusis.
Due to the rising number of the aged human population all over the world, presbycusis is a phenomenon that deserves the increasing attention of the medical community as regards to prevention and treatment. This requires finding appropriate animal models for human presbycusis that will be useful in future experiments. Among the available rat strains, the Fischer 344 (F344) strain promises to ser...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 1998
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/42.1.1