Towards unified vesicle endocytosis

Dissecting Synaptic Vesicle Endocytosis

Synaptic vesicle endocytosis.

Exocytosis of synaptic vesicles is followed rapidly by reinternalization and recycling of their membranes. Recent studies have confirmed the key role of clathrin-mediated endocytosis in synaptic vesicle reformation and have identified new proteins that participate in this process. In addition, growing evidence suggests that lipids, primarily phosphoinositides, play an important role in synaptic...

Synaptic Vesicle Recycling: The Ferrari of endocytosis?

After neurotransmission, neurons internalize and recycle the membrane components of synaptic vesicles remarkably quickly; they may have a 'rebuilt, turbo-charged' endocytic engine to achieve these speeds.

Mixing and Matching during Synaptic Vesicle Endocytosis

The question of how synapses maintain an active recycling pool of synaptic vesicles to support high-frequency synaptic transmission has been a perplexing and often controversial problem. In this issue of Neuron, Fernandez-Alfonso et al. present data indicating that at least two synaptic vesicle proteins, synaptotagmin 1 and VAMP-2, are present in a large pool on the synaptic and axonal plasma m...

Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis

Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby sug...