Towards the Preparation of Novel Re/99mTc Tricarbonyl-Containing Peptide Nucleic Acid Bioconjugates
نویسندگان
چکیده
منابع مشابه
Metal-containing peptide nucleic acid conjugates.
Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugate...
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A fast and economical procedure for the production of peptide nucleic acid (PNA) microarrays is presented. PNA oligomers are synthesized in a fully automatic manner in 96-well plates using standard Fmoc chemistry. Subsequently, the oligomers are released from the support and spotted onto glass or silicone slides, which were activated by succinimidyl ester. This process allows for a concomitant ...
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Background & Objectives: Antisense peptide nucleic acids (PNA) that target growth essential genes show potent bactericidal properties without cell lysis. We considered the possibility that whether PNA treatment influence the bacteria total nucleic acids content and apply approach to develop a new delivery system to Dendritic cells (DCs). DCs are the most potent antigen presenting cells in th...
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Department of Chemistry, University of Zu Zurich, Switzerland. E-mail: gilles.ga gassergroup.com; Tel: +41 44 635 46 30 Helmholtz-Zentrum Dresden – Rossendorf, Research, Bautzner Landstraße 400, [email protected]; Web: http://www.hzdr.d 3091 Lehrstuhl für Anorganische Chemie I – Bioa und Biochemie, Ruhr-Universität Bochum, U Germany † Electronic supplementary information PNAs used this study (Fi...
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ژورنال
عنوان ژورنال: Australian Journal of Chemistry
سال: 2011
ISSN: 0004-9425
DOI: 10.1071/ch11010