Towards Quality Control for DNA Microarrays
نویسندگان
چکیده
منابع مشابه
Towards Quality Control for DNA Microarrays
We present a framework for detecting probes in oligonucleotide microarrays that may add significant error to measurements in hybridization experiments. Four types of so-called degenerate probe behavior are considered: secondary structure formation, self-dimerization, cross-hybridization, and dimerization. The framework uses a well-established model for computing the free energy of nucleic acid ...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2004
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2004.11.945