Toward Prospective Prediction of Pharmacokinetics in OATP1B1 Genetic Variant Populations
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چکیده
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Toward Prospective Prediction of Pharmacokinetics in OATP1B1 Genetic Variant Populations
Physiologically based pharmacokinetic (PBPK) models are increasingly being used to provide human pharmacokinetic (PK) predictions for organic anion-transporting polypeptide (OATP) substrates based on in vitro assay data. As a natural extension in the application of these models, in this study, we incorporated in vitro information of three major OATP1B1 genetic variants into a previously reporte...
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ژورنال
عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology
سال: 2014
ISSN: 2163-8306
DOI: 10.1038/psp.2014.50