Toward more effective gene delivery

Challenges and Perspectives toward Development of more Effective Influenza Vaccine

Influenza viruses continue to be a major health threat in human and bird populations. The improvements in formulation and production level of the current influenza vaccines are not sufficient to afford complete protection. The continuous antigenic drifts and emergence of endemic and zoonotic strains make influenza vaccine planning difficult. Concern about the emergence of new influenza pandemic...

Optimization of the piggyBac Transposon Using mRNA and Insulators: Toward a More Reliable Gene Delivery System

Integrating and expressing stably a transgene into the cellular genome remain major challenges for gene-based therapies and for bioproduction purposes. While transposon vectors mediate efficient transgene integration, expression may be limited by epigenetic silencing, and persistent transposase expression may mediate multiple transposition cycles. Here, we evaluated the delivery of the piggyBac...

Uncovering Bias: Toward a More Effective Voir Dire

Judge Mark W. Bennett of the Northern District of Iowa calls himself a “true believer” of implicit bias, having instructed jurors on this subject for more than 8 years from the bench. He has developed a set of jury instructions to educate jurors on the existence of their biases and holds them accountable by signing their name consenting to be fair during trial. To emphasize the importance of th...

Toward a more effective and efficient communication process.

Toward a More Effective Intravascular Cell Therapy in Stroke