Tough Times for Medicinal Chemists: Are We to Blame?

Tough times call for tough decisions.

Visualization of chemical space for medicinal chemists

One of the most common tasks that cheminformatics experts in pharmaceutical industry are facing practically daily is analysis and visualization of large collections of molecules. Typical areas, where this is needed are analysis and enhancement of company compound archive, analysis of high-throughput screening data, design of combinatorial libraries, chemogenomics analyses and many others. But a...

Molecular Targets for Endometriosis Therapy: Where We Are and Where We Are Going?

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Should medicinal chemists do molecular modelling?

In this article we discuss the pros and cons of medicinal chemists undertaking three-dimensional (3D) computer-aided drug design (CADD) activities for themselves, from the viewpoint of both medicinal chemists and computational chemists. We describe how best this can be implemented, the potential benefits that can be obtained and the pitfalls that are often encountered.

Re-aim blame for NIH's hard times.

ANXIETY AND ANGER ARE RIFE AMONG THE BIOMEDICAL RESEARCH COMMUNITY OVER THE dwindling fortunes of the National Institutes of Health (NIH). The anxiety is justified: Success rates for grant applications have fallen, on average, from over 30% in 2003 to under 20% (and to even less at some Institutes), and the Bush administration’s budget projections imply further declines. But the anger is anothe...