Total Raltegravir Concentrations in Cerebrospinal Fluid Exceed the 50-Percent Inhibitory Concentration for Wild-Type HIV-1
نویسندگان
چکیده
منابع مشابه
Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1.
HIV-associated neurocognitive disorders continue to be common. Antiretrovirals that achieve higher concentrations in cerebrospinal fluid (CSF) are associated with better control of HIV and improved cognition. The objective of this study was to measure total raltegravir (RAL) concentrations in CSF and to compare them with matched concentrations in plasma and in vitro inhibitory concentrations. E...
متن کاملDarunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration.
OBJECTIVES Higher CSF antiretroviral concentrations may be associated with better control of HIV replication and neurocognitive performance, but only the unbound fraction of antiretrovirals is available to inhibit HIV. Therefore, the objective of this study was to determine total and unbound darunavir concentrations in CSF and compare findings with plasma concentrations as well as the wild-type...
متن کاملRaltegravir Cerebrospinal Fluid Concentrations in HIV-1 Infection
INTRODUCTION Raltegravir is an HIV-1 integrase inhibitor currently used in treatment-experienced HIV-1-infected patients resistant to other drug classes. In order to assess its central nervous system penetration, we measured raltegravir concentrations in cerebrospinal fluid (CSF) and plasma in subjects receiving antiretroviral treatment regimens containing this drug. METHODS Raltegravir conce...
متن کاملCerebrospinal fluid nerve growth factor and total protein concentration in the children with meningitis
Meningitis is one of the most common infectious cerebral nervous system (CNS), defined as an inflammation of the meninges. It is clinically categorized into a chronic and acute based on the acuity of symptoms. Vomiting, bulging fontanel and fever are the main symptoms in the patients with meningitis. Bacterial meningitis is a severe, potentially life-threatening infection that is associated wit...
متن کاملThe Comparison of Leukemia Inhibitory Factor (LIF) Concentration in the Serum and Cerebrospinal Fluid of Children with Bacterial Meningitis
Abstract Background and objectives: Meningitis is one of the most common infectious of the central nervous system (CNS), defined as an inflammation of the meninges. LIF is a potent pro-inflammatory factor. Cerebrospinal fluid (CSF) contains the growth factors and cytokines whose concentrations have been changed in most neurological diseases. The aim of this study was to determine the LIF conce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2010
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00507-10