Total fertilization failure and molecular abnormalities in metaphase II oocytes
نویسندگان
چکیده
منابع مشابه
Efficiency of metaphase II oocytes following minimal/mild ovarian stimulation in vitro fertilization
BACKGROUND An inverse relationship between oocyte efficiency and ovarian response was reported in conventional IVF. The purpose of this study was to report metaphase II (MII) oocyte efficiency according to oocyte yield in minimal/mild stimulation IVF (mIVF) and to assess whether oocyte yield affects live birth rate (LBR). METHODS Infertile women (n = 264) aged < 39 years old with normal ovari...
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The spindle apparatus is a vital structure and must be structurally intact for proper segregation of the oocyte's genetic material during metaphase II. Endometriosis, oxidative stress, and cryopreservation can all adversely affect the structural integrity of the spindle, potentially resulting in aneuploidy and spontaneous abortion of the embryo. Advances in spindle imagery have made it possible...
متن کاملchromosomal abnormalities in failed fertilized oocytes following in vitro fertilization
introduction: the types and incidence of the chromosomal abnormalities in failed fertilized oocytes that were taken after routine in vitro fertilization (ivf) and intracytoplasmic sperm injection (icsi) programs were investingated in patients referred the royan institute. materials and method: in this study, 364 air-dried preparation of failed fertilized oocytes after either ivf (91 samples) or...
متن کاملMultiparameter analysis of human oocytes at metaphase II stage after IVF failure in non-male infertility.
BACKGROUND Using fluorescence imaging, an a posteriori multiparametric analysis was performed of human oocytes which failed to give pronucleated zygotes after IVF in cases of very low rates of fertilization or complete fertilization failure. METHODS The analysis included: (i) the state of the maternal and paternal chromatin; (ii) quality of the metaphase II oocytes; and (iii) cortical granule...
متن کاملAge-Associated Lipidome Changes in Metaphase II Mouse Oocytes
The quality of mammalian oocytes declines with age, which negatively affects fertilization and developmental potential. The aging process often accompanies damages to macromolecules such as proteins, DNA, and lipids. To investigate if aged oocytes display an altered lipidome compared to young oocytes, we performed a global lipidomic analysis between oocytes from 4-week-old and 42 to 50-week-old...
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ژورنال
عنوان ژورنال: Reproductive BioMedicine Online
سال: 2008
ISSN: 1472-6483
DOI: 10.1016/s1472-6483(10)60404-x