Torque teno virus loads after kidney transplantation predict allograft rejection but not viral infection

The main challenge of immunosuppressive therapy after solid organ transplantation is to create a new immunological balance that prevents rejection and does not promote opportunistic infection. Torque teno virus (TTV), ubiquitous non-pathogenic single-stranded DNA virus, has been proposed as marker functional immunity in immunocompromised patients. Here we investigate whether TTV loads predict the risk common viral infection allograft kidney recipients. In retrospective cohort 389 recipients, individual were measured by qPCR consecutive plasma samples during one year follow-up. endpoints rejection, BK polyomavirus (BKPyV) viremia cytomegalovirus (CMV) viremia. Repeated measurements survival data analysed joint model. During follow-up, detection transplant recipients increased from 85 100%. median load 107 genome copies/ml within three months transplantation. Rejection, BKPyV CMV occurred 23%, 27% 17% patients, respectively. With every 10-fold load-increase, decreased considerably (HR: 0.74, CI 95%: 0.71–0.76), while remained same 1.03, 1.03–1.04 HR: 1.01, 1.01–1.01). conclusion, kinetics but potential use levels guide for optimal drug dosage prevent deserves further validation.