TORn about SASP regulation

On Feeling Torn About One’s Sexuality

Three studies offer novel evidence addressing the consequences of explicit-implicit sexual orientation (SO) ambivalence. In Study 1, self-identified straight females completed explicit and implicit measures of SO. The results revealed that participants with greater SO ambivalence took longer responding to explicit questions about their sexual preferences, an effect moderated by the direction of...

On Feeling Torn About One's Sexuality: The Effects of Explicit

Three studies offer novel evidence addressing the consequences of explicit–implicit sexual orientation (SO) ambivalence. In Study 1, self-identified straight females completed explicit and implicit measures of SO. The results revealed that participants with greater SO ambivalence took longer responding to explicit questions about their sexual preferences, an effect moderated by the direction of...

SASP reflects senescence

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

Endothelial cell senescence is characterized by acquisition of senescence-associated secretory phenotype (SASP), able to promote inflammaging and cancer progression. Emerging evidence suggest that preventing SASP development could help to slow the rate of aging and the progression of age-related diseases, including cancer. Aim of this study was to evaluate whether and how adalimumab, a monoclon...

SASP: roadblock for tissue re-organization

has been shown to prevent and promote tumorigenesis. [1, 2] These results are not so paradoxical. To develop and maintain, organisms rely on cellular growth and cell division. Each of these processes is spatiotemporally finely tuned and both are tightly coordinated to ensure organism homeostasis throughout life. As organism aged, deregulations of these processes appear leading to hyperplastic o...