TOR-driven aging: Speeding car without brakes
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چکیده
منابع مشابه
Release the brakes and fly without fear.
ULTIMATELY, YOU have to take action for positive change to occur. Attitude gives the thrust, but action provides the vector. You can break the safety fear barrier at work. As I write this article at my favorite Starbucks, I can't help but hear the conversation next to me. A middle-aged woman is having a coffee meeting with a peer; they discuss job opportunities, the market, and their personal n...
متن کاملHormesis does not make sense except in the light of TOR-driven aging
Weak stresses (including weak oxidative stress, cytostatic agents, heat shock, hypoxia, calorie restriction) may extend lifespan. Known as hormesis, this is the most controversial notion in gerontology. For one, it is believed that aging is caused by accumulation of molecular damage. If so, hormetic stresses (by causing damage) must shorten lifespan. To solve the paradox, it was suggested that,...
متن کاملGCN2 and TOR converge on aging
ensure the survival of an organism in periods of food unavailability. Two evolutionarily conserved, nutrient-sensing signaling pathways that promote stress adaptation following starvation are the general amino acid control pathway that activates GCN2 kinase and the target of rapamycin (TOR) kinase pathway [1]. In response to amino acid deprivation GCN2 is activated, upon binding of uncharged tR...
متن کاملTOR-dependent cerebrovascular aging in Alzheimer’s disease
Increasing evidence suggests that vascular dysfunction, a universal feature of aging, mechanistically contributes to the onset and pathogenesis of neurological diseases of aging. It was recently discovered that attenuating activity of the mammalian/mechanistic target of rapamycin (mTOR) extends both lifeand health-span in mice by delaying aging. Here we review current evidence for a critical ro...
متن کاملTOR‐mediated regulation of metabolism in aging
Cellular metabolism is regulated by the mTOR kinase, a key component of the molecular nutrient sensor pathway that plays a central role in cellular survival and aging. The mTOR pathway promotes protein and lipid synthesis and inhibits autophagy, a process known for its contribution to longevity in several model organisms. The nutrient-sensing pathway is regulated at the lysosomal membrane by a ...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2009
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.8.24.10310