TOPPER: Topology Prediction of Transmembrane Protein Based on Evidential Reasoning

TOPPER: Topology Prediction of Transmembrane Protein Based on Evidential Reasoning

The topology prediction of transmembrane protein is a hot research field in bioinformatics and molecular biology. It is a typical pattern recognition problem. Various prediction algorithms are developed to predict the transmembrane protein topology since the experimental techniques have been restricted by many stringent conditions. Usually, these individual prediction algorithms depend on vario...

Prediction of Transmembrane Protein Topology Based on Power Average Operator

The prediction of the topology of transmembrane proteins is an important foundation in the research of bioinformatics. In this paper, information fusion theory has been introduced to locate the transmembrane regions and find their orientation. The proposed method, which is on the basis of the power average operator and a kind of similarity degree of interval numbers, considers a transmembrane r...

A Transmembrane Topology Prediction Method Based on Integration Mechanism

Transmembrane Protein Alignment and Fold Recognition Based on Predicted Topology

BACKGROUND Although Transmembrane Proteins (TMPs) are highly important in various biological processes and pharmaceutical developments, general prediction of TMP structures is still far from satisfactory. Because TMPs have significantly different physicochemical properties from soluble proteins, current protein structure prediction tools for soluble proteins may not work well for TMPs. With the...

Topology Prediction of α-Helical Transmembrane Proteins –

Membrane proteins fulfil a number of tasks in cells, including signalling, cell-cell interaction, and the transportation of molecules. The prominence of these tasks makes membrane proteins an important target for clinical drugs. Because of the decreasing price of sequencing, the number of sequences known is increasing at such a rate that manual annotations cannot compete. Here, topology predict...