Topological mimicry and epitope duplication in the guanylyl cyclase C receptor
نویسندگان
چکیده
منابع مشابه
Glycosylation of human receptor guanylyl cyclase C
Background Post translational modifications regulate several signalling pathways and glycosylation is emerging as a key player in this regulatory process. Glycosylation of cell surface receptors modulate the downstream signalling pathway and when altered causes a change in the normal physiology of the cell [1]. Guanylyl cyclase C (GC-C) belongs to a group of membrane bound receptors that produc...
متن کاملRole for the membrane receptor guanylyl cyclase-C in attention deficiency and hyperactive behavior.
Midbrain dopamine neurons regulate many important behavioral processes, and their dysfunctions are associated with several human neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD) and schizophrenia. Here, we report that these neurons in mice selectively express guanylyl cyclase-C (GC-C), a membrane receptor previously thought to be expressed mainly in the intesti...
متن کاملThe linker region in receptor guanylyl cyclases is a key regulatory module: mutational analysis of guanylyl cyclase C.
Receptor guanylyl cyclases are multidomain proteins, and ligand binding to the extracellular domain increases the levels of intracellular cGMP. The intracellular domain of these receptors is composed of a kinase homology domain (KHD), a linker of approximately 70 amino acids, followed by the C-terminal guanylyl cyclase domain. Mechanisms by which these receptors are allosterically regulated by ...
متن کاملNO signalling in mice lacking the NO receptor guanylyl cyclase
NO-sensitive guanylyl cyclase (NO-GC) is accepted to be the major receptor for the signaling molecule NO. NO-GC catalyzes the production of the intracellular second messenger cGMP and thereby has a key regulatory function regarding various physiological processes. NO-GC is made up of one β subunit and one α subunit. On the protein level, there are two α subunits (α1 and α2) and one β subunit (β...
متن کاملTitle: The Role of Guanylyl Cyclase C During Intestinal Adaptation
Introduction: Following a proximal small bowel resection (SBR), the intestine adapts by increased crypt depth and villus height compared to sham operated mice (transection and reanastomosis only). The epidermal growth factor receptor (EGFR) is a known mediator of intestinal adaptation and results in activation of the GTPase Rac. This activates PAK (p21-activated protein kinase) which may activa...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1998
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560071015