Topically Applied Diacylglycerols Increase Pigmentation in Guinea Pig Skin

Topically applied ceramide accumulates in skin glyphs

Ceramides (CERs), structural components of the stratum corneum (SC), impart essential barrier properties to this thin outer layer of the epidermis. Variations in CER species within this layer have been linked to several skin diseases. A recent proliferation of CER-containing topical skin-care products warrants the elucidation of CER penetration profiles in both healthy and diseased skin. In the...

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits α-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish...

Guinea-pig Skin in Tissue Culture

Small pieces of guinea-pig skin were exposed to a uniform field of microwaves at X-band (8,730 MHz). Measurements showed that 26%of the incident energy was reflected, 34% was absorbed, and the remaining 40% was transmitted. Absorbed energy was converted to heat, causing a rise in the temperature of the skin. After exposure to microwaves the skin was maintained in vitro on a nutrienmedium. Uptak...

Karyotype of Hairless Guinea pig

Chromosomal patterns of experimental animals are useful tools for cytogenetics research and animal breeding. Chromosome investigations of the hairless guinea pig are rare, therefore, karyotype of hairless guinea pigs (twelve male and female) was studied using metaphase spreads of bone marrows and G banding techniques. The chromosomes diploid number was 2n= 64 and polymorphism of three type chro...

PACAP-Induced Increase in Excitability in Guinea Pig Intracardiac Neurons