Topical steroid-damaged skin

Phase IIB Randomized Study of Topical Difluoromethylornithine and Topical Diclofenac on Sun-Damaged Skin of the Forearm.

Prevention of nonmelanoma skin cancers remains a health priority due to high costs associated with this disease. Diclofenac and difluoromethylornithine (DFMO) have demonstrated chemopreventive efficacy for cutaneous squamous cell carcinomas. We designed a randomized study of the combination of DFMO and diclofenac in the treatment of sun-damaged skin. Individuals with visible cutaneous sun damag...

Topical Skin Rejuvenation Treatments

There are hundreds if not thousands topical skin rejuvenation treatments on the market, from wrinkle creams to eye serums to lifting gels. If all of them worked as advertised, anyone with a bit of extra cash could have a skin of a fifteen year old. In reality, relatively few topical agents are clinically proven to improve wrinkles and other signs of skin aging. Others are supported by some posi...

Topical Skin Care

Prospective Trial Comparing Topical Steroid Application To Wet Versus Dry Skin In Children With Atopic Dermatitis

PROSPECTIVE TRIAL COMPARING TOPICAL STEROID APPLICATION TO WET VERSUS DRY SKIN IN CHILDREN WITH ATOPIC DERMATITIS. Lucinda S. Liu, Yanna Kang, and Richard J. Antaya. Department of Dermatology, Yale University School of Medicine, New Haven, CT. The aim of this study was to determine whether “soak and smear,” a technique where hydration via a 10-minute soak in lukewarm plain water followed by top...

Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin

We have investigated the efficacy of conditioning skin Langerhans cells (LCs) with agents to promote tolerance and reduce inflammation, with the goal of improving the outcomes of antigen-specific immunotherapy. Topical treatments were assessed ex vivo, using excised human breast skin maintained in organ bath cultures, and in vivo in healthy volunteers by analysing skin biopsies and epidermal bl...