Topical ophthalmic lipid nanoparticle formulations (SLN, NLC) of indomethacin for delivery to the posterior segment ocular tissues
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چکیده
منابع مشابه
Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides.
Purpose To evaluate the efficacy of anti-VEGF agents for treating choroidal neovascularization (CNV) when delivered topically using novel cell-penetrating peptides (CPPs) compared with delivery by intravitreal (ivit) injection. Methods CPP toxicity was investigated in cell cultures. Ivit concentrations of ranibizumab and bevacizumab after topical administration were measured using ELISA. The ...
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An inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has traveled a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fatwater-fat structure of the corneal barrier, while ensuring minimum wastage t...
متن کاملOcular Drug Delivery: Targeting the Posterior Segment
One inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has come a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fat-water-fat structure of the corneal barrier while ensuring minimum wastage thro...
متن کاملDevelopment of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery.
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitr...
متن کاملOcular Iontophoresis for Anterior and Posterior Segment Drug Delivery
Over the recent decades, there has been seismic shift in the field of ocular drug delivery ranging from dosage form design to drug product commercialization. Advancements in the fields of nanotechnology, biomedical engineering and clinical science significantly improved the feasibility of ocular drug delivery. Despite these technological advances, there exists need to deliver drugs in therapeut...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2016
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2016.10.015