Topical Imiquimod Treatment of Lentigo Maligna
نویسندگان
چکیده
منابع مشابه
Treatment of lentigo maligna with topical imiquimod.
A published case report and anecdotal experience suggested that topical imiquimod is an effective treatment for stage 0 melanoma (lentigo maligna). To gauge the efficacy of this therapy, we undertook a trial of topical imiquimod in 30 subjects with histologically confirmed lentigo maligna. Thirty subjects with lentigo maligna were recruited for an open-labelled efficacy trial with daily topical...
متن کاملTopical Imiquimod Treatment of Lentigo Maligna
Lentigo maligna (LM) is the in situ phase of lentigo maligna melanoma, which may progress to invasive melanoma if left untreated. It mainly occurs on sun-exposed areas of elderly patients. The lesions can be large and conventional surgery can be difficult, particularly on the face. Recent reports indicate that topical imiquimod 5% cream is effective in the treatment of LM. It may be an alternat...
متن کاملEffect of topical imiquimod as primary treatment for lentigo maligna: the LIMIT-1 study.
BACKGROUND Topical imiquimod is sometimes used for lentigo maligna (LM) in situ melanoma instead of surgery, but frequency of cure is uncertain. Pathological complete regression (pCR) is a logical surrogate marker for cure after imiquimod, although residual LM and atypical melanocytic hyperplasia may not be reliably distinguished. A trial comparing imiquimod vs. surgery might be justified by a ...
متن کاملObservational Study of Topical Imiquimod Immunotherapy in the Treatment of Difficult Lentigo Maligna
Introduction Lentigo Maligna (LM) typically presents at sun-exposed sites in elderly patients as an asymmetric, slow-growing, irregularly pigmented macule with an irregular indented border. With changes in sun exposure behaviour LM is becoming more prevalent in middle-aged and younger adults.1 The risk of melanoma developing in LM increases with duration of the disease and therefore age,2 and i...
متن کاملTreatment of lentigo maligna and lentigo maligna melanoma.
Thirty-eight cases of lentigo maligna and 22 cases of lentigo maligna melanoma, were reviewed in order to compare cure rates of various methods of treatment. Surgical excision resulted in the best cure rate (91%); destructive modalities were less successful (45%). All lesions treated with 5% 5-fluorouracil recurred.
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ژورنال
عنوان ژورنال: Case Reports in Dermatology
سال: 2009
ISSN: 1662-6567
DOI: 10.1159/000249151