Topical capsaicin application causes cold hypersensitivity in awake monkeys
نویسندگان
چکیده
منابع مشابه
Topical capsaicin application causes cold hypersensitivity in awake monkeys.
Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys. Two monkeys were trained to detect a change in cold stimulus temperature (30 degrees C to 0.5, 1.0, 1.5 or 2.0 degrees C) applied to the facial...
متن کاملPattern evoked potentials in awake rhesus monkeys.
The pattern evoked potential (EP) in man to checkerboard stimulation has been shown to consist of various components originating in different regions of the visual cortex. Surface recordings, however, cannot unambiguously localize the sources of these components; for precision, depth recordings seem to be indicated. Considering the close correspondence in cortical architecture to man, rhesus mo...
متن کاملReal-Time Dopamine Measurement in Awake Monkeys
Fast-scan cyclic voltammetry (FSCV) is often used to measure real-time dopamine (DA) concentrations in awake, behaving rodents. Extending this technique to work in monkeys would provide a platform for advanced behavioral studies and a primate model for preclinical research. The present study demonstrates the feasibility of DA recordings in two awake monkeys (Macaca mulatta) using a mixture of t...
متن کاملCold Hypersensitivity in Raynaud's Phenomenon
nomenon. The method used was to examine the magnitude and time-course of the reflex vasoconstriction in the hand which follows application of ice to the neck. One hand of each subject was kept at 260C and the other at 360C, while the general thermal environment was varied. Enhancement was found in three groups of subjects: those with idiopathic, early age-onset, Raynaud's disease; those with Ra...
متن کاملCapsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation
Capsaicin has been used in clinical applications for the treatment of pain disorders and inflammatory diseases. Given the strong pungency and high oil/water partition coefficient of capsaicin, capsaicin-loaded nanolipoidal carriers (NLCs) were designed to increase permeation and achieve the analgesic, anti-inflammatory effect with lower skin irritation. Capsaicin-loaded NLCs were prepared and l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Oral Science
سال: 2008
ISSN: 1880-4926,1343-4934
DOI: 10.2334/josnusd.50.175