منابع مشابه
Topical analgesics.
BACKGROUND AND OBJECTIVES Pain treatment involves the usage of common and opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics. Traditionally, these drugs are administered systemically or into the neuraxis. However, when analgesics are applied through these pathways, they are associated with significant side effects, which can hinder its use. Topical administ...
متن کاملTopical and peripherally acting analgesics.
Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the peripheral activation of primary sensory afferent neurons. The localized peripheral administration of drugs, such as by topical application, can potentially optimize drug concentrations at the site of origin of the pain, while leading to lower systemic levels and fewer adverse systemic effects, fewer drug int...
متن کاملRecent Findings Surrounding Topical Antidepressants as Analgesics and Review of Existing and Emerging Topical Analgesics*
Tricyclic antidepressants (TCAs) have been used for chronic pain management for decades; however, their potential use as topical analgesics is an area of new research. This article highlights recent findings relating to the mode of action of TCAs and summarizes results of animal testing of these agents as analgesics. A review of existing and emerging information regarding localized peripheral a...
متن کاملCompounded Topical Analgesics for Chronic Pain.
Analgesic medications compounded for topical use are gaining popularity for the management of chronic pain. The advantages of topical pain medications include reduction of systemic adverse effects, improved patient acceptance, few drug interactions, ease of dose determination, avoidance of first-pass metabolism, and direct access to the target site. Compounded topical medications typically use ...
متن کاملTopical analgesics in the management of acute and chronic pain.
Oral analgesics are commonly prescribed for the treatment of acute and chronic pain, but these agents often produce adverse systemic effects, which sometimes are severe. Topical analgesics offer the potential to provide the same analgesic relief provided by oral analgesics but with minimal adverse systemic effects. This article describes the results of a systematic review of the efficacy of top...
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ژورنال
عنوان ژورنال: Brazilian Journal of Anesthesiology
سال: 2012
ISSN: 0034-7094
DOI: 10.1016/s0034-7094(12)70122-8