Tonic-Clonic Transitions in Computer Simulation

Tonic-clonic transitions in computer simulation.

SUMMARY Network simulations can help identify underlying mechanisms of epileptic activity that are hard to isolate in biologic preparations. To be useful, simulations must be sufficiently realistic to make possible biologic and clinical prediction. This requirement for large networks of sufficiently detailed neurons raises challenges both with regard to computational load and the difficulty of ...

Disinhibition-induced transitions between absence and tonic-clonic epileptic seizures

Electrophysiological experiments have long revealed the existence of two-way transitions between absence and tonic-clonic epileptic seizures in the cerebral cortex. Based on a modified spatially-extended Taylor &Baier neural field model, we here propose a computational framework to mathematically describe the transition dynamics between these epileptic seizures. We first demonstrate the existen...

Tonic clonic status epilepticus.

Oxaliplatin-Induced Tonic-Clonic Seizures

Oxaliplatin is a common chemotherapy drug used for colon and gastric cancers. Common side effects are peripheral neuropathy, hematological toxicity, and allergic reactions. A rare side effect is seizures which are usually associated with posterior reversible leukoencephalopathy syndrome (PRES). A 50-year-old male patient presented with severe abdominal pain. CT scan of the abdomen showed acute ...

Tonic-clonic seizures in patients taking sildenafil.

indicate continuing sequelae of the fracture or that people fracturing their neck of femur are more frail and ill than the general population of similar age. Measures of prognosis after fracture and comparisons between hospitals are substantially affected by whether death registration data are included, whether time intervals are extended beyond 30 days, and whether deaths that are not certifie...