Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse
نویسندگان
چکیده
منابع مشابه
Systemic Toll-Like Receptor Stimulation Suppresses Experimental Allergic Asthma and Autoimmune Diabetes in NOD Mice
BACKGROUND Infections may be associated with exacerbation of allergic and autoimmune diseases. Paradoxically, epidemiological and experimental data have shown that some microorganisms can also prevent these pathologies. This observation is at the origin of the hygiene hypothesis according to which the decline of infections in western countries is at the origin of the increased incidence of both...
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INTRODUCTION TOLL-LIKE RECEPTORS: KEY RECEPTORS OF THE INNATE IMMUNE SYSTEM The human body constantly encounters a diverse spectrum of pathogens. To defend itself, a complex immune system has evolved consisting of two subdivisions: the innate and the adaptive immune systems. The innate immune system constitutes the so-called “first line of defense” and acts through highly conserved germline-enc...
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Although it is established that defective clearance and, hence, increased accumulation of apoptotic cells can lead to autoimmunity, the mechanism by which this occurs remains elusive. Here, we observed that apoptotic cells undergoing secondary necrosis but not intact apoptotic cells provoked substantial immune responses, which were mediated through the toll-like receptor 2 (TLR2) pathway. The d...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2011
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-011-2083-y