Tolerogenic immunosuppression for organ transplantation
نویسندگان
چکیده
منابع مشابه
Immunosuppression in organ transplantation.
The immunological barrier remains the major obstacle to the widespread use of transplantation as a replacement therapy for terminal organ failure. Since the first successful renal transplant, performed by Hume et al. (1952), there has been an elusive search for agents that can render the immune mechanism unresponsive to the specific alloantigen stimulus of the engrafted organ, while sparing non...
متن کاملCurrent Immunosuppression in Abdominal Organ Transplantation
Organ transplantation has saved the lives of thousands of patients beginning from the mid 1950s. At the end of 2007 the Organ Procurement and Transplantation Network (OPTN) database recorded 183,222 people living with a functioning graft in the United States (Wolfe et al., 2010). Over the last two decades survival rates have continued to improve and currently 81-91% of kidney transplant recipie...
متن کاملTolerance in Organ Transplantation: From Conventional Immunosuppression to Extracellular Vesicles
Organ transplantation is often the unique solution for organ failure. However, rejection is still an unsolved problem. Although acute rejection is well controlled, the chronic use of immunosuppressive drugs for allograft acceptance causes numerous side effects in the recipient and do not prevent chronic allograft dysfunction. Different alternative therapies have been proposed to replace the cla...
متن کاملTolerogenic therapies in transplantation
Since the concept of immunologic tolerance was discovered in the 1940s, the pursuit of tolerance induction in human transplantation has led to a rapid development of pharmacologic and biologic agents. Short-term graft survival remains an all-time high, but successful withdrawal of immunosuppression to achieve operational tolerance rarely occurs outside of liver transplantation. Collaborative ef...
متن کاملTolerogenic Mechanisms in Liver Transplantation
incidence of rejection compared with other solid organs, and spontaneous acceptance of the liver graft with successful discontinuation of immunosuppression has been reported in nearly 20% of LT recipients [10,11]. Multiple studies have suggested the protective effect of the liver allograft in Simultaneous Liver-Kidney Transplantation (SLKT) compared with recipients of isolated renal transplants...
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ژورنال
عنوان ژورنال: The Lancet
سال: 2003
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(03)13175-3