منابع مشابه
Bioactivation of organic nitrates and the mechanism of nitrate tolerance.
Organic nitrates, such as nitroglycerin, are commonly used in the therapy of cardiovascular disease. Long-term therapy with these drugs, however, results in the rapid development of nitrate tolerance, limiting their hemodynamic and anti-ischemic efficacy. In addition, nitrate tolerance is associated with the expression of potentially deleterious modifications such as increased oxidative stress,...
متن کاملTolerance to the organic nitrates: new ideas, new mechanisms, continued mystery.
Nitroglycerin (NTG) and other organic nitrates continue to be important drugs that are often used in cardiovascular medicine. All organic nitrates undergo denitrification, releasing nitric oxide (NO) through a biotransformation process that remains poorly understood to date. NO activates the enzyme soluble guanylyl cyclase in smooth muscle cells, causing increased levels of the second messenger...
متن کاملNEAT HFpEF: Organic nitrates fail to deliver
Received: 8 November 2015 Accepted: 29 January 2016 c © 2016 The Author(s), licensee Magdi Yacoub Institute. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY-4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. Cite this article as: Wagdy K, Hassan M. NEAT HFpEF...
متن کاملTolerance to organic nitrates: evidence, mechanisms, clinical relevance, and strategies for prevention.
OBJECTIVE To review the available information about nitrate tolerance, its potential mechanisms, clinical implications, and strategies for prevention. DATA IDENTIFICATION A survey of the National Library of Medicine MEDLINE database and bibliographies of the reviewed articles. STUDY SELECTION AND DATA EXTRACTION Studies were selected from the English language literature with an emphasis on ...
متن کاملNitrate tolerance, oxidative stress, and mitochondrial function: another worrisome chapter on the effects of organic nitrates.
A shortcoming in the clinical use of organic nitrates is the development of tolerance. Recent data have suggested that the denitrification of organic nitrates is mediated by mitochondrial aldehyde dehydrogenase and that dysfunction of this enzyme is an important cause of tolerance. In this issue of the JCI, evidence in support of this hypothesis is presented in an in vivo model of nitrate toler...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circ.104.19.2263