Tolerability of NXY-059 at Higher Target Concentrations in Patients With Acute Stroke
نویسندگان
چکیده
منابع مشابه
Tolerability of NXY-059 at higher target concentrations in patients with acute stroke.
BACKGROUND AND PURPOSE NXY-059 is a nitrone-based free radical-trapping agent in development for acute stroke. In patients with acute stroke, NXY-059 is well tolerated at concentrations known to be associated with neuroprotection in animal models of transient cerebral ischemia; however, higher target concentrations appear necessary on the basis of animal models of permanent ischemia. METHODS ...
متن کاملTolerability and pharmacokinetics of the nitrone NXY-059 in patients with acute stroke.
BACKGROUND AND PURPOSE Increased free radical formation contributes to the damage caused to the brain by acute ischemia. NXY-059 is a nitrone-based free radical trapping agent in development for acute stroke. NXY-059 has neuroprotective efficacy when given 5 hours after onset of transient focal ischemia in the rat. METHODS This was a randomized, double-blind, placebo-controlled, parallel grou...
متن کاملNXY-059 for acute ischemic stroke.
BACKGROUND NXY-059 is a free-radical-trapping agent that is neuroprotective in animal models of stroke. We tested whether it would reduce disability in humans after acute ischemic stroke. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 1722 patients with acute ischemic stroke who were randomly assigned to receive a 72-hour infusion of placebo or intravenous...
متن کاملNXY-059: a hopeful sign in the treatment of stroke.
The SAINT I trial published in the February 9, 2006 issue of the New England Journal of Medicine represents the first “positive” neuroprotective trial in stroke.1 This breaks a long string of “neuroprotective” failures and indicates some hope for stroke treatment.2 Is NXY-059 a better drug than previous failed agents or was the trial just better designed? Probably both. NXY-059 is the first age...
متن کاملSafety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial.
BACKGROUND AND PURPOSE NXY-059 is a free radical-trapping neuroprotectant developed for use in acute ischemic stroke. To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the safety of NXY-059 in patients with intracerebral hemorrhage (ICH). METHODS We randomized 607 patients within 6 hours of acute ICH to receive 2270 mg intravenous NXY-059 over ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2003
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000053032.14223.81