to study the Hemodynamic effects of intravenous clonidine as premedication for endotracheal intubation

Direct laryngoscopy and intubation can lead to increase in heart rate blood pressure by 20-27% 30-50% respectivelyIt produces stimulation of laryngeal tracheal sensory receptors resulting a marked the release sympathetic amines may cause hypertensive crisis.Clonidine has anti-hypertensive properties helps enhance effects anaesthetic agents while decreasing their requirements intraoperatively simultaneously also providing post operative analgesia, hence we consider it be an ideal agent blunt pressor response intubation. Here have studied clinical efficacy intravenous clonidine alpha 2 agonist dose 1mcg/kg as pre medication for endotracheal patients undergoing general anaesthesia There was significant difference haemodynamic parameters such rate, systolic diastolic pressures mean arterial without much change from baseline premedicated with compared those who were placebo, immediately at 5 minutes Clonidine given intravenously premedication safely attenuate