To fold or not to fold: modulation and consequences of Hsp90 inhibition
نویسندگان
چکیده
منابع مشابه
hsp90: Twist and Fold
Molecular chaperones are cellular machines that facilitate protein folding. The crystal structures of HtpG, the Escherichia coli homolog of hsp90, reported in this issue (Shiau et al., 2006) together with the recently published structures of an hsp90-cochaperone complex (Ali et al., 2006) and an hsp90-client protein complex (Vaughan et al., 2006), reveal exciting insights into the hsp90 reactio...
متن کامل"Do not fold, spindle, or mutilate".
Imagine that you get such certain awesome experience and knowledge by only reading a book. How can? It seems to be greater when a book can be the best thing to discover. Books now will appear in printed and soft file collection. One of them is this book do not fold spindle or mutilate. It is so usual with the printed books. However, many people sometimes have no space to bring the book for them...
متن کاملTo fold or expand--a charged question.
I t is no secret anymore that many proteins “defy” the common paradigm and do not fold to a welldefined 3D structure under native conditions. These are the so-called intrinsically disordered proteins (IDPs) (1). Some of these proteins do fold upon binding to a target (2), whereas others do not seem to fold under any known conditions. Much has been written in recent years about the connection be...
متن کاملTo fold, first unfold
The double-ringed GroEL chaperone complex is well-known for capturing partially folded proteins and confi ning them within its central cavity to facilitate folding. GroEL is especially important to proteins that have a complex folding pattern, such as Rubisco. A prominent model of GroEL function suggests that the chaperone fi rst partially unfolds its substrate, disrupting misfolded and inhibit...
متن کاملFrom fold to function.
A number of recent advances have been made in deriving function information from protein structure. A fold relationship to an already characterized protein will often allow general information about function to be deduced. More detailed information can be obtained using sequence relationships to already studied proteins. Methods of deducing function directly from structure, without the use of e...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2009
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc.09.17