منابع مشابه
To be, or not to be immunocompetent
Several data support the view that impairment of the inflammatory-immune response is a hallmark of severe sepsis and the level and time of recovery to immunocompetence has a major impact on the clinical outcome of ICU patients. Recent studies demonstrate that improvement of anti-tumour immune response by targeting negative regulatory molecules, such as CD25, chronic T-lymphocyte activation anti...
متن کاملASK "to be, or not to be?".
“To be, or not to be? That is the question.” William Shakespeare, The Tragedy of Hamlet, Prince of Denmark (1599-1602). Viral infection triggers host defense mechanisms that include the production of type I interferon (IFN) and the induction of apoptosis. Type I IFN, such as IFN-α and IFN-β, establishes the antiviral state to inhibits viral replication within infected cells, whereas apoptosis o...
متن کاملTo be or not to be B7.
The activation of lymphocytes and development of adaptive immune responses is initiated by the engagement of TCRs by antigenic peptide-MHC complexes and shaped at the clonal level by both positive and negative costimulatory signals. The B7 family members are involved at several stages in this process. In this issue of the JCI, Vogt et al. show that the B7 family-related protein V-set and Ig dom...
متن کاملTo Be or Not to Be
Suicidal ideation is a key concept to prevent suicide [1]. South Korea marks the highest record for suicidal attempts within the Organization for Economic Co-operation and Development (OECD) countries [2]. Suicide, along with cancer and cardiovascular diseases is one of the leading causes of death in Korea. It is also the first leading cause of death for teens and people in their 20s, second fo...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2013
ISSN: 1364-8535
DOI: 10.1186/cc12897