TNF-α Involvement in Insulin Resistance Induced by Experimental Scorpion Envenomation
نویسندگان
چکیده
منابع مشابه
TNF-α Involvement in Insulin Resistance Induced by Experimental Scorpion Envenomation
BACKGROUND Scorpion venom induces systemic inflammation characterized by an increase in cytokine release and chemokine production. There have been few experimental studies assessing the effects of scorpion venom on adipose tissue function in vivo. METHODOLOGY/PRINCIPAL FINDINGS To study the adipose tissue inflammation (ATI) induced by Androctonus australis hector (Aah) venom and to assess pos...
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This study aimed to evaluate the clinical, histopathological and hematological effects of Mesobuthus eupeus venom on chicken organs. Adult chickens were subcutaneously injected with five doses of M. eupeus venom (0.5, 2, 5, 10 and 20 mg/kg; four chickens per each dose). Symptoms were recorded during the experiment and blood samples were collected for hematological analysis. Moreover, a complete...
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In Algeria scorpion envenomation represents a real public health problem with a population at risk of scorpion stings estimated at 68% of the national population. A total of 903, 461 scorpion sting cases and 1996 deaths were recorded by health services between 1991 and 2012. The physical-geographic and climate conditions make the province of Naama a conducive environment for scorpion species an...
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Scorpions are nocturnal arthropods that inject their venom through the victims' skin by stingers. By the envenomation, clinical manifestations in a wide spectrum may occur, including pain at one side and death because of severe cardiopulmonary or neurological abnormalities. Sometimes the victim cannot describe the insect or does not remember even being stung after the event. We present two case...
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Visceral fat is strongly associated with insulin resistance. Obesity-associated adipose tissue inflammation and inflammatory cytokine production are considered key mediators of insulin signaling inhibition. TWEAK is a relatively new member of the TNF cytokine superfamily, which can exist as full length membrane-associated (mTWEAK) and soluble (sTWEAK) isoforms. Although TWEAK has been shown to ...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2012
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001740