TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein
نویسندگان
چکیده
منابع مشابه
Important role for the transmembrane domain of severe acute respiratory syndrome coronavirus spike protein during entry.
The spike protein (S) of severe acute respiratory syndrome coronavirus (SARS-CoV) is responsible for receptor binding and membrane fusion. It contains a highly conserved transmembrane domain that consists of three parts: an N-terminal tryptophan-rich domain, a central domain, and a cysteine-rich C-terminal domain. The cytoplasmic tail of S has previously been shown to be required for assembly. ...
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Department of Microbiology and Molecular Genetics, Harvard Medical School and New England Primate Research Center, Southborough, Massachusetts; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Laboratory of Molecular Medicine, Children’s Hospital, Boston, Massachusetts; Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Berlin, Germany...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X
DOI: 10.1128/jvi.02202-13