TMEM16 as calcium-activated chloride channels
نویسندگان
چکیده
منابع مشابه
TMEM16 proteins: the long awaited calcium-activated chloride channels?
Currents mediated by calcium-activated chloride channels (CaCCs), observed for the first time in Xenopus oocytes, have been recorded in many cells and tissues ranging from different types of neurons to epithelial and muscle cells. CaCCs play a role in the regulation of excitability in neurons including sensory receptors. In addition, they are crucial mediators of chloride movements in epithelia...
متن کاملCalcium-activated chloride channels.
Calcium-activated chloride channels (CaCCs) play important roles in cellular physiology, including epithelial secretion of electrolytes and water, sensory transduction, regulation of neuronal and cardiac excitability, and regulation of vascular tone. This review discusses the physiological roles of these channels, their mechanisms of regulation and activation, and the mechanisms of anion select...
متن کاملFunctional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle.
Airway smooth muscle hyperresponsiveness is a key component in the pathophysiology of asthma. Although calcium-activated chloride channel (CaCC) flux has been described in many cell types, including human airway smooth muscle (HASM), the true molecular identity of the channels responsible for this chloride conductance remains controversial. Recently, a new family of proteins thought to represen...
متن کاملTMEM16 chloride channels are two-faced
The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 148 No. 5 367–373 https://doi.org/10.1085/jgp.201611686 367 Elucidating the oligomeric structure of ion channels is central to understanding their function (Marsh and Teichmann, 2015). The vast majority of ion channels are formed by multiple subunits organized as an annulus surrounding a solitary, centrally located ion-conductin...
متن کاملTMEM16 chloride channels are two-faced
The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 148 No. 5 367–373 https://doi.org/10.1085/jgp.201611686 367 Elucidating the oligomeric structure of ion channels is central to understanding their function (Marsh and Teichmann, 2015). The vast majority of ion channels are formed by multiple subunits organized as an annulus surrounding a solitary, centrally located ion-conductin...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2013
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.142.144