TLR agonist combinations that stimulate Th type I polarizing responses from human neonates

The role of type I interferons in TLR responses.

Recent advances in unravelling the complexities of the signalling pathways that constitute innate immunity have highlighted type I interferon as a key component in the response to infection. Here we focus on the emerging field of pattern-recognition receptor signalling, specifically Toll-like receptors and retinoic acid inducible gene-like helicases, from the perspective of this 50-year-old cyt...

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in non-human primates Authors

Toll-like receptor ligands (TLR-L) represent novel vaccine adjuvants, but their immunological effects in humans in-vivo remain poorly defined. Here we analyzed the innate responses stimulated by different TLR-L in rhesus macaques, a relevant preclinical model for vaccine testing. MPL (TLR4-L), R-848 (TLR7/8-L) or CpG-ODN (TLR9-L) induced rapid (3hr) and robust (>92% of WBC) expansion of blood n...

TLR Agonists Stimulate Nlrp3-Dependent

Generalized Weighted Composition Operators From Logarithmic Bloch Type Spaces to $ n $'th Weighted Type Spaces

Let $ mathcal{H}(mathbb{D}) $ denote the space of analytic functions on the open unit disc $mathbb{D}$. For a weight $mu$ and a nonnegative integer $n$, the $n$'th weighted type space $ mathcal{W}_mu ^{(n)} $ is the space of all $fin mathcal{H}(mathbb{D}) $ such that $sup_{zin mathbb{D}}mu(z)left|f^{(n)}(z)right|begin{align*}left|f right|_{mathcal{W}_...

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates.

TLR ligands (TLR-Ls) represent novel vaccine adjuvants, but their immunologic effects in humans remain poorly defined in vivo. In the present study, we analyzed the innate responses stimulated by different TLR-Ls in rhesus macaques. MPL (TLR4-L), R-848 (TLR7/8-L), or cytosine-phosphate-guanine oligodeoxynucleotide (TLR9-L) induced a rapid and robust expansion of blood neutrophils, with a concom...