منابع مشابه
How I treat refractory acute GVHD.
Graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT) is associated with considerable morbidity and mortality, particularly in patients who do not respond to primary therapy, which usually consists of glucocorticoids (steroids). Approaches to therapy of acute GVHD refractory to "standard" doses of steroids have ranged from increasing the dose of steroids to ...
متن کاملSteroid-Refractory Acute GVHD: Predictors and Outcomes
Patients with steroid-resistant acute graft versus host disease (aGVHD) have a dismal prognosis, with mortality rates in excess of 90%. We sought to identify a subgroup of patients less likely to benefit from initial therapy with corticosteroids as well as the impact of response on day 14 on outcome. Retrospective evaluation was performed of patients with biopsy-proven aGVHD treated with cortic...
متن کاملLimited efficacy and tolerance of imatinib mesylate in steroid-refractory sclerodermatous chronic GVHD.
Imatinib mesylate (IM), a tyrosine kinase inhibitor, has shown efficacy for the treatment of chronic GVHD (cGVHD),1-3 with overall response rates of fibrotic skin symptoms evaluated in 2 open-label studies ranging from 50%1 to 79%.2 To assess the global long-term effectiveness of IM for sclerodermatous cGVHD, we performed a retrospective study on 39 patients with steroidresistant disease follow...
متن کاملEqual opportunity targeting in chronic GVHD.
In this issue of Blood, studies by Rangarajan et al comprehensively analyzing the clonotypic T-cell response provide evidence that the effector T cells that mediate chronic GVHD may have a unique specificity that includes recognition of self.1 G raft-versus-host disease is the major complication that occurs after allogeneic bone marrow transplantation (BMT) and is classically thought to be the ...
متن کاملInternational Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2012
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2012.240