Tissue specific expression of alternatively spliced Murine PECAM-1 isoforms

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Tissue specific expression of alternatively spliced murine PECAM-1 isoforms.

PECAM-1 (CD31) is a cell adhesion molecule that is highly expressed at the sites of endothelial cell-cell contact and at lower levels on the surface of platelets and leukocytes. It is a member of the immunoglobulin gene superfamily and undergoes alternative splicing to generate several isoforms that differ only in their cytoplasmic domains. The tissue distribution of the expression of different...

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Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms.

Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a cell adhesion molecule that is highly expressed on the surface of endothelial cells and some hematopoietic cells. Its cytoplasmic domain is encoded by multiple exons, which undergo alternative splicing. Here, we demonstrate that the human PECAM-1 cytoplasmic domain undergoes alternative splicing, generating six different isoforms. RT-...

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Expression pattern of alternatively spliced PECAM-1 isoforms in retinal vasculature.

PURPOSE Platelet/endothelial cell adhesion molecule-1 (PECAM-1) is a cell adhesion-signaling molecule with important roles in angiogenesis and inflammation. The alternative splicing of the PECAM-1 cytoplasmic domain modulates its adhesive properties during vascular development and angiogenesis. This study was designed to identify alternatively spliced PECAM-1 isoforms in human and murine retina...

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Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development.

The establishment of the cardiovascular system represents an early, critical event essential for normal embryonic development. An important component of vascular ontogeny is the differentiation and development of the endothelial and endocardial cell populations. This involves, at least in part, the expression and function of specific cell surface receptors required to mediate cell-cell and cell...

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EASI—enrichment of alternatively spliced isoforms

Alternative splicing produces more than one protein from the majority of genes and the rarer forms can have dominant functions. Instability of alternative transcripts can also hinder the study of regulation of gene expression by alternative splicing. To investigate the true extent of alternative splicing we have developed a simple method of enriching alternatively spliced isoforms (EASI) from P...

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ژورنال

عنوان ژورنال: Developmental Dynamics

سال: 1999

ISSN: 1058-8388,1097-0177

DOI: 10.1002/(sici)1097-0177(199901)214:1<44::aid-dvdy5>3.0.co;2-l