Tissue-Specific and Differential Cold Responses in the Domesticated Cold Tolerant Fugu

Domestication can be defined as the artificial selection in animals to achieve morphological, physiological, and developmental conformity human needs, with aim of improving various limitations species under a feeding environment. The future sustainability aquaculture may rely partly on availability numerous domesticated fish species. However, underlying adaptive mechanisms that result domestication are still unclear. Because they poikilothermic, temperature is key environmental element affects entire life fish, so studying association between physiological behavioral changes low-temperature provide model for understanding response cold stress. Through 5 generations 10 years at low temperatures, we used cold-tolerant fugu biological compare transcriptome brain liver tissues study effects stress fish. It was found expression genes such apoptosis, p53, oxidative phosphorylation, mitochondrial ?-oxidation significantly lower than wild type due stress, while excessive energy metabolism would lead production reactive oxygen (ROS) exacerbate damage, thus causing rollover coma. Meanwhile, signaling pathways involved glycogenolysis lipid metabolism, insulin signaling, adipocytokines, mTOR pathways, were up-regulated fugu. Although pathway increased tissues, not enriched apoptotic. These phenomena predict conditions, employs dynamic inter-organ metabolic regulation strategy cope reduce damage tissues.