Tissue distribution of cholesterol and 24-dehydrocholesterol during chronic triparanol therapy
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منابع مشابه
Tissue Distribution of Cholesterol and 24-dehydrocholesterol during Chronic Triparanol Therapy.
The tissues of five patients who died following 4-31 months of continuous oral triparanol therapy have been analyzed for sterol content by gas-liquid chromatographic techniques. Desmosterol was present in variable amounts in all tissues examined, with the exception of nervous tissue, but in none of the tissues did desmosterol constitute a larger fraction of total sterols than that observed in t...
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Triparanol (/3-L-diethylaminoethoxyphenyl-l-[-ptolyl]-2-p-chlorophenyl)* is an efficient inhibitor of endogenous cholesterol biosynthesis (Blohm and MacKenzie, 1959). It seems to prevent the conversion of 24-dehydrocholesterol (desmotserol) to cholesterol (Avigan, Steinberg, Thompson, and Mosettig, 1960; Frantz, Mobberley, and Schroepfer, 1960). Recently, it has been shown that triparanol, in d...
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IN a recent communication (2), it was demonstrated that in human subjects receiving triparanol therapy, 24-dehydrocholesterol (desmosterol) could serve as a direct precursor of several physiologically important compounds normally derived from cholesterol. The results indicated the direct conversion of desmosterol to both bile acids and to steroid hormones in these patients, and suggested that d...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1965
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)39637-1