TISSUE DISTRIBUTION AND FUNCTIONAL CHARACTERIZATION OF ORGANIC CATION/CARNITINE TRANSPORTER OCTN1
نویسندگان
چکیده
منابع مشابه
Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).
It has been reported that organic cation/carnitine transporter 1 (OCTN1) is associated with rheumatoid arthritis and Crohn's disease. Additionally, we reported that OCTN1 is expressed in hematopoietic cells, and is associated with proliferation and differentiation of erythroid cells. However, physiological role of OCTN1 is still unclear. Ergothioneine, an anti-oxidant, was recently reported to ...
متن کاملFunctional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.
Carnitine/organic cation transporter (OCTN1/SLC22A4) accepts various therapeutic agents as substrates in vitro and is expressed ubiquitously, although its function in most organs has not yet been examined. The purpose of the present study was to evaluate functional expression of OCTN1 in small intestine and liver, using octn1 gene knockout [octn1(-/-)] mice. After oral administration of [(3)H]e...
متن کاملFunctional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
We have demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a transporter for organic cations as well as carnitine. OCTN2 transports organic cations without involving Na(+), but it transports carnitine only in the presence of Na(+). The ability to transport organic cations and carnitine is demonstrable with human, rat, and mouse OCTN2s. Na(+) does not influence t...
متن کاملIdentification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.
The mitochondrial carriers are a family of transport proteins that, with a few exceptions, are found in the inner membranes of mitochondria. They shuttle metabolites and cofactors through this membrane, and connect cytoplasmic functions with others in the matrix. SAM (S-adenosylmethionine) has to be transported into the mitochondria where it is converted into S-adenosylhomocysteine in methylati...
متن کاملExpression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium.
PURPOSE The existence of an organic cation transport process in rabbit cornea and conjunctiva that mediates absorption of carnitine has previously been suggested. This study was conducted to determine the expression and localization of the carnitine/organic cation transporter (OCTN1 and OCTN2) in corneal or conjunctival epithelium. METHODS Reverse transcriptase-polymerase chain reaction (RT-P...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 2001
ISSN: 0916-1139
DOI: 10.2133/dmpk.16.supplement_114