Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma
نویسندگان
چکیده
منابع مشابه
Tiotropium bromide step-up therapy for adults with uncontrolled asthma.
BACKGROUND Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed. METHODS In a three-way, double-blind, triple-dummy crossover trial involving 210 patients with asthma, we evaluated the addition of tiotropium bromide (a long-acting anticho...
متن کاملStep-up therapy for children with uncontrolled asthma.
Robert F. Lemanske, Jr., M.D., David T. Mauger, Ph.D., Christine A. Sorkness, Pharm.D., Daniel J. Jackson, M.D., Susan J. Boehmer, M.S., Fernando D. Martinez, M.D., Robert C. Strunk, M.D., Stanley J. Szefler, M.D., Robert S. Zeiger, M.D., Ph.D., Leonard B. Bacharier, M.D., Ronina A. Covar, M.D., Theresa W. Guilbert, M.D., Gary Larsen, M.D., Wayne J. Morgan, M.D., Mark H. Moss, M.D., Joseph D. S...
متن کاملRole of Tiotropium as Step Up Therapy for Asthma
Background: To determine the role of Tiotropium as step up therapy for patients with uncontrolled asthma. Methods: In this case control study 130 patients, with diagnosis of bronchial asthma for at least 01 year and presently on step 4 treatment and still symptomatic, were included . Sixty five patients were randomly assigned to receive Tiotropium bromide dried inhaler added to their convention...
متن کاملTiotropium bromide is effective for severe asthma with noneosinophilic phenotype.
Although currently available asthma medications are very effective in the majority of cases, there remains a subgroup for which disease control is difficult. Anticholinergics have long been used to treat asthma, although their current role in therapy is supplementary [1]. Tiotropium bromide, a recently developed anticholinergic, is a long-acting bronchodilator with a well-established effectiven...
متن کاملTiotropium bromide
Therapy with bronchodilators forms the pharmacologic foundation of the treatment of patients with COPD. Bronchodilators can significantly lessen dyspnea, increase airflow, improve quality of life, and enhance exercise performance. While bronchodilators decrease airway resistance and lessen dynamic hyperinflation in patients with COPD, they have not been shown to alter the rate of decline in FEV...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2010
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa1008770